Peptide Insulin-like Growth Factor-1 (IGF-1): IGF-1 LR3 VS IGF-1 DES

Insulin-like Growth Factor-1 (IGF-1): IGF-1 LR3 VS IGF-1 DES 

 

IGF-1 (Insulin-like growth factor) is an endocrine hormone that is produced in the liver. The production of IGF-1 is increased in the presence of growth hormone. IGF stands for insulin-like growth factor. Insulin-like growth factor 1 (IGF-1) is a polypeptide protein hormone similar in molecular structure to insulin . It plays an important role in childhood growth and continues to have effects in adults. It is a natural substance that is produced in the human body and is at its highest natural levels during puberty. During puberty IGF is the most responsible for the natural muscle growth that occurs during these few years. There are many different things that IGF does in the human body. Among the effects the most positive are increased amino acid transport to cells, increased glucose transport, increased protein synthesis, decreased protein degradation, and increased RNA synthesis.

IGF-1 Benefits:

Why is this IGF-1 important for a bodybuilder or athlete? Let’s take a look at the list:

• Helps regulate fat for use as energy, resulting in fat loss.
• Contributes to anti aging. As we get older, IGF-1 production slows down and this results in cell reduction. Low levels of IGF-1 are linked to heart failure, lower brain cell regulation and neuron function. Not to mention muscle tissue breakdown.
• Helps to increase nutrient shuttling (protein synthesis).
• Increases regenerative functions of nerve tissues.
• Boosts the ability to cause hyperplasia in muscle cells resulting in fuller muscle tissue.

IGF-1 LR3 Details:

Product Name	IGF-1 LR3
Also known as	R3 IGF1, R3 IGF-1, R3IGF1, R3IGF-1, LONG IGF1, LONG IGF-1, LONG R3 IGF1, LONG R3IGF1, LONG R3 IGF-1, LONG R3IGF-1
Appearance	Sterile Filtered White lyophilized (freeze-dried) powder
Standard	Pharmaceutical
Purity	Not Lower Than 95.00%
Source	Escherichia Coli
Application Type	Injection
Supplying Form	Lyophilized Powder In Vials
Customized	Supported. ①. Various Colors of Flip off Caps ②. 1mg/vial, 2mg/vial, 5mg/vial, 10mg/vial , or no vials . order more than 1000mg, we can make it 1mg*1000bottles, 2mg*100 bottles, 5mg * 200 bottles, 10mg * 100 bottles up to your demand. ③. Peptides Blend According to Your Demand. such as CJC GHRP2 Combo, CJC Ipamorelin Combo……
Solubility	It is recommended to reconstitute the lyophilized LR3 IGF1 in sterile 18M-cm H2O

IGF-1 LR3 Purity:

Greater than 90.0% as determined by SDS-PAGE. actually above 95%.

IGF-1 LR3 Formulation:
Lyophilized from a 0.2 μm filtered solution of 300mM HAc-NaAc, pH 6.5.

LR-3 IGF-1 Application:

-average 14% of fat decrease
-average 8.8% increase the structures of the body and lean muscle
-Improved skin texture resulting in a more youthful appearance
-Remove the wrinkles from skin
-Increased bone density, stopped osteoporosis
-Faster healing of any type of injury, fracture, or wound
-Significantly increased immunity and resistance to infection
-Increased brain function, retention of intellect with aging
-Improvement of Alzheimer and Parkinson syndromes
-Improved sex drive
-The improvement in the fullest physical and mental well-being
-Improved training tolerance
-Improved mood, less depression and fatigue
-Improved heart and kidney function
-Large cardiac output
-Cellulite disappearing
-Cartilage regeneration
Indication:
-Body building
-Anti – aging
-Fat Loss
-Get taller
-Any cases of diabetes

IGF-1 LR3 Specification:

Product Name	Recombinant Insulin Like Growth Factor 1, Long R3
Source	WUMEITECH
Catalog No.	WM20688
Physical Appearance	White lyophilized powder
Formulation	LR3 IGF-1 is lyophilized with saline.
Purity	＞95%
Datesheet	Available
Endotoxin	Less than 1EU/mg
Restrictions	FOR RESEARCH, LABORATORY AND MANUFACTURE USE ONLY. NOT INTENDED FOR DIRECT USE ON HUMANS.
Specification available	0.1mg/vial (recommended) IGF-1 LR3 10vial=1kit 1mg/vial IGF-1 LR3 10vial=1kit
MOQ	10vial, 1kit
Stock	Available in stock

Why use IGF-1?

To put it simply, the gains from IGF-1 (all variants) are not due to water weight, so the gains you will achieve will be long term muscle growth. This is compared to steroids, which are renowned for putting on water weight and giving you nasty side effects. You are not going to gain 10lbs from using IGF-1, but you will see solid 1-2lbs gains every 1-2 weeks.

The most important factor to consider is IGF-1’s ability to achieve hyperplasia. When you use steroids, they will help the body through hypertrophy, which means you are increasing the size of the existing muscle cells. On the other hand, IGF-1 will cause hyperplasia, which means you are actually increasing the number of cells in the muscle tissue. These new cells can be utilized through further training, and use of steroids, to make bigger muscles. Essentially, you will have the ability to achieve more muscle density and size at the genetic level by using IGF-1.

IGF-1 Variants:

IGF-1 variants are split into two groups: IGF-1 LR3 and DES IGF-1 (usually presented as IGF-1 DES). Base IGF-1 has a very short half life (about 10-20 minutes); as a result, it is quickly destroyed by the body. This is why IGF-1 was modified to make the amino acid analog IGF-1 LR3 (Long). The other variant of IGF-1 called DES IGF-1 is a truncated version that is 10X more potent than IGF-1. Both variants are similar to its root but have different actions, allowing them to function in a specific ways.

IGF-1 LR3

Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or LR3-IGF-1, is a synthetic protein and lengthened analogue ofhuman insulin-like growth factor 1 (IGF-1). IGF-1 LR3 has a half-life of about 20-30 hours and is much more potent than base IGF-1. Since its half-life is about a day, the IGF-1 LR3 will circulate the body, for around 24 hours, binding to receptors and activating cell communication that improves muscle growth and fat loss.

LR3 prevents glucose from entering into cells, which, in turn, forces the body to burn fat and not sucrose. In addition, its long half-life is desirable for another reason; site injections aren’t necessary, as IGF-1 LR3 will cycle the body binding to all muscle cells for about a day.

Long R3 IGF-1 is signifacantly more potent than IGF-1. The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF’s.

The amino acid sequence of IGF-1 LR3 is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.

IGF-1 DES

DES IGF-1 is the shorter version of the IGF-1 chain. It is five (5) times more powerful than IGF-LR3 and ten (10) times more powerful than regular base IGF-1. The half-life for DES is about 20-30 minutes, which means this is a very delicate chain. Therefore, administration should only be done at the site where you want to see muscle growth. DES has the ability to stimulate muscle hyperplasia better than LR3. In simple terms, it’s best used for site injections, rather than overall growth.

des(1-3)IGF-1 lacks the first three amino acids at the N-terminus of IGF-1 (for a total of 67 amino acids, relative to the 70 of IGF-1). As a result of this difference, it has considerably reduced binding to the insulin-like growth factor-binding proteins (IGFBPs) and enhanced potency  relative to IGF-1.

The amino acid sequence of des(1-3)IGF-1 is TLCGAELVDA LQFVCGDRGF YFNKPTGYGS SSRRAPQTGI VDECCFRSCD LRRLEMYCAP LKPAKSA.

In addition, DES is known to bind to receptors that have been deformed by lactic acid, which is often present during workouts. This allows the DES to attach itself to a mutated receptor and signal tissue growth during training. DES can be used longer and more frequently than LR3.

IGF-1 Cycle, Dosing and Injections:

The most effective length for a cycle of IGF is 50 days on and 20-40 days off. The most controversy surrounding Long R3 IGF-1 is the effective dosage.

The most used dosages range between 20mcg/day to 120+mcg/day. IGF is only available by the milligram, one mg will give you a 50 day cycle at 20mcg/day, 2mg will give you a 50 day cycle at 40mcg/day, 3mg will give you a 50 day cycle at 60mcg/day, 4mg will give you a 50 day cycle at 80mcg/day and so on.

IGF-1 LR3

IGF-1 LR3 can be taken 7 days a week at a dose of 50-150mcg a day. Desensitization was shown to occur at around 40 days or roughly 4 weeks. Injection sites can be at any muscle group on the body, as it’s not very good at site specific growth.

 

DES IGF-1 can be dosed at 50-150mcg multiple times a day (prior to training) into specific target areas. since DES has such a short half life (20-30 minutes), desensitization was not noticed at all . Injection sites should be localized; preferably, at the muscle group you want to grow. In simple terms, if you want to grow your biceps, inject IGF-1 DES right into your bicep.

IGF-1 Side Effects:

It should be noted that high doses of IGF-1 have been known to cause hypoglycemia, but nowhere near the level of insulin. It is also noted, and highly debated, that IGF-1 was shown to increase tumor size in cancer patients. While this fact may be true in patients with existing cancer, IGF-1 is not the cause of cancer; in fact, our bodies need IGF-1 to regulate heart function, nervous system and brain cell stimulation. People with low IGF-1 levels were found to have low protein counts and low lean body mass, which, in turn, can be equally unhealthy. If you have a headache, you don’t take a whole bottle of Aspirin. Likewise, to guard yourself from making ignorant mistakes, IGF-1 should be administered properly , and never abused.

IGF-1 LR3 Pictures

Long Arg3 Insulin-like Growth Factor-I (Long-R3-IGF-I) is an 83 amino acid analog of IGF-I comprising the complete IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. Long-R3-IGF-I is significantly more potent than IGF-I in vitro. The enhanced potency is due to the markedly decreased binding of Long-R3-IGF-I to IGF binding proteins which normally inhibit the biological actions of IGFs.

Quick Guide:
1. Swab the top of your sterile vial with alcohol prep pad (70% isopropyl alcohol)
2. Mix 7.5mL distilled water with 1.0mL vinegar
3. Add Whatman syringe filter
4. Add sterile ~20ga. needle to end of Whatman filter
5. Inject the 8.5mL of solution into the sterile vial
6. You now have sterile 0.6% acetic acid

Reconstituting IGF-1 LR3:

Reconstitution is simply the addition of the 0.6% AA to your lyophilized IGF-1.
Assumption: 1mg/mL IGF-1/AA (1mg IGF-1 will be combined with 1mL AA; 1mg IGF-1 is the same as 1,000mcg)

1. Swab the top of your IGF-1 vial with a sterile alcohol prep pad
2. Swab the top of your 0.6% AA vial with a sterile alcohol prep pad
3. Using either multiple insulin syringe volumes (example: 2 x 0.5cc) or a single large syringe, obtain 1.0mL of 0.6% AA.
4. In the IGF-1 vial, insert a sterile ~20 ga. needle to act as a vent
5. Inject the 1.0mL of AA very slowly and dribble it down the side of the vial.
a. Be very careful with this peptide as it is very delicate!
6. Remove the needle & syringe and discard
7. Gently swirl the vial or roll between your hands.
a. Again, be very gentle here
8. You now have 1mg/mL of IGF-1
a. This is the same as: 1,000mcg/mL

Now you can order IGF-1 LR3 from WUMEITECH, quality peptide and best service as aways!

If you have question, contact our service person, we will get back to you timely.

An Article by evolutionary. Edited by Wumei Tech. Email: info@wumeitech.com. All Rights Reserved.